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Pragmatic trials are trials designed to provide information for the real-world practice of clinical. They are typically focused on the practical aspects of the research design, like recruitment and consent in adherence, as well as the use of routinely available equipment.
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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results is also essential. However too much heterogeneity could lead to issues with the design of the trial.
Pragmatic Play, one of the biggest players on the live casino market, offers a variety of classic table games such as Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer a real-life gambling experience for customers, as well as an extensive selection of virtual betting options. The company also has several games which make online gambling exciting and interactive. Some of these shows have live hosts, while others are hosted by famous personalities from the industry.
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The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be a great method to determine the cause-effect relationship between the intervention and its effects. However, they should not, be used to replace explanation studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study, including recruitment, design, delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember that the majority were conducted in primary-care settings.